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Zignifica is Next Generation Evaluation of Clinical Research - Zignifica

Zignifica is Next Generation Evaluation of Clinical Research

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If you want to base health decisions on trustworthy evidence – whether you are a provider or someone seeking healthcare – here is how Zignifica is your guide and how Zignifica is the soulution of today.

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Zignifica Evidence Based medicine Classification


Zignifica Classification System

Zignifica has a unique classification system to present the evaluation of individual medical papers. In Zignifica is a comprehensive analysis of a medical paper automated based on artificial intelligence. The review is not just limited to see if the method used in the study are sound and following validated and recommended techniques, but also include evaluating metadata like in/exclusion criteria, and publication of study plan prior to starting the study, and more.

An evaluation of the clinical relevance of the design and method of the study including the adequacy of the study population and outcome assessments is part of the Zignifica analysis. Zignifica also analyses the power of the results not just by statistical strength but much more important for the clinical relevance of the findings.

All this, and much more, are included in the Zignifica Classification presenting two scores going from 0 to 100, one score for method and design, and one score for the results. Zignifica translates these scores into an easily understandable grading with sub-grading from A to F with text explaining the evaluation.

UpToDate and other Tools

Several other tools like UptoDate”, “Trip”, and others manually select and evaluate individual papers based the “Grade system” or other systems evaluating the scientific method used in the studies in some cases combined with analysis of findings across studies of the same topic. Here are some of these:
“Center for Evidence-Based Medicine Oxford,” which is a grading system based on the type of study with systematic reviews of randomised controlled studies having the highest validity, especially with consistent results between studies, and with expert opinions and case studies having the lowest validity.
Grade System. “UptoDate” are based this classification system going from A to C (or sometimes D), where the highest classification (A) is for consistent results form more than one study and the lowest score is for expert opinions and case studies. The Grade system also includes a number 1 or 2 to signify the strength of a recommendation. “UptoDate” is a decision support system for clinical problems by presenting a collection of recommendations based on the Grade system. The UpToDate recommendations are written and updated manually by an editorial team, and based on papers selected by this editorial team. 
Sort system. This is a method for the meaningfulness of outcome for patients such as symptom relief, risk reduction, etc. used in a study. It does not include an evaluation of the clinical significance of the individual paper’s findings.

Some tools, like “Trip,” include being published in a high ranking journal like “New England Journal of Medicine” as a measure of quality which, unfortunately, it is not.

Bottom Line

Zignifica, in contrast to other tools and classifications, have a comprehensive classification system based on the clinical relevance of the findings, and the clinical significance and validity of scientific method used to find these. Furthermore, is the evaluation presented in a format including explanatory text, understandable for healthcare providers and persons without a medical education. Using automated processes and artificial intelligence allows Zignifica to make a real-time analysis of published articles in contrast to systems where humans are selecting individual papers and analyzes them. Zignifica also enables the user to synthesise their own meta-analysis based on clinical significance across published papers for a specific treatment or condition.