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Home - Zignifica
  • Zignifica - Your guide to Precision Evidence

    For Healthcare Professionals, Patients, Caregivers, News media, Payers and many more
  • Clinical Relevancy Matters

    Support us on our quest to include clinical significance when reporting on Clinical Trials
  • Zignifica is on a mission to bring precision evidence to the point-of-care

    Zignifica is a Start-Up Health Company

Challenges with Clinical Research

New research is published every 25 seconds and is added to a large universe of existing research. It’s impossible to keep up to date reading the new research using humans alone. A general practitioner would have to read 29 hours per day to keep up with the latest research.

Only 15% of this published research provides useful and meaningful results for patients. That means that physicians, care teams, patients, caregivers, and payers have to not only read all the most up-to-date evidence available, but they have no way of identifying the signal from the noise. 

Health practitioners who want to apply the latest evidence based medicine can not just rely on guidelines, as it takes on average 2 to 5 years before research makes it into guidelines.

Our Solution

A SaaS platform to evaluate published clinical research and score it based on its clinical significance

Method & Design

Zignifica analyses the method and the design that was used to the conduct the research itself. This is based on any pre-registration and the published report itself (full paper) and focuses on areas such as duration of trials, trial-design, participation and drop-outs.


Zignifica analyses the statistical as well as the clinical significance of the findings that are included in the research. The clinical significance is centered around the concepts of Minimal Clinically Important Difference (MCID) and Number Needed to Treat (NNT).

Research Areas

Zignifica has algorithms & classification systems related to Virus infections, Infections in general, Oncology, COPD, Cardiovascular disease including hypertension, Diabetes, (Chronic) Pain, Depression, Osteoporosis, Infertility, Diagnostic test/screening studies, Diagnostic radiology, Epidemiology.

Check out our Podcast Series

'The Precision Evidence Podcast'

How does it work

Our approach

1. Extract

Capture relevant data points from newly identified research paper

2. Score

Score both the method/design as well as the clinical results

3. Classify

Provide overall rating from A (very clinical significant) to F (no clinical significance) including reason codes

4. Categorize

Labeling data / research to enable relevancy/matching (precision)

5. Simplify

Creation of easy understandable abstract

At the point of care

Zignifica can be used as a stand-alone solution or can be integrated with EMRs.

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